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[DOI] [PMC free article] [PubMed] [Google Scholar] 79.Pilon-Smits E.H.A

Using a conservative two-tailed analysis, we found a significant increase in the Kyn/Trp ratio in symptomatic TTR-V30M patients compared with healthy controls ( p = 0.0009

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The pharmacokinetic rationale is questionable given tirzepatide 5-day half-life

However, no significant differences were observed in the SGRQ-C total score