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Early-stage trial disclosures referenced tolerability issues like persistent injection-site reactions
This slower conversion reduces the likelihood of abrupt changes in serotonin transporter expression, possibly making it better tolerated in individuals with autism who are sensitive to methylation shifts
Interpretation by a qualified provider is essential for clinical application
Patients should be counseled to drink sufficient water throughout the day and to increase intake during episodes of nausea, vomiting, or diarrhea
The intestinal epithelium itself is composed of multiple specialized cell types, each with distinct physiological, metabolic, and transport activity, introducing further complexity to absorption and limiting the translational predictability of preclinical models that lack the complete representation of these cell populations (Liebing et al., 2025)
Each participant completed a questionnaire as a baseline, then another at a one-month follow-up
