The main benefits of GLP-1 therapy include: Enhanced insulin secretion in response to meals Reduced glucagon release, preventing high blood sugar levels Slowed gastric emptying, leading to prolonged satiety Decreased appetite, which may help with weight loss Currently available GLP-1 receptor agonists include drugs like liraglutide (Victoza), semaglutide (Ozempic, Wegovy), exenatide (Byetta), and dulaglutide (Trulicity)
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In that trial, nausea was reported in approximately 4560% of participants (varying by dose), diarrhoea in approximately 3040%, vomiting in approximately 2030%, and constipation in a smaller proportion
Managing the gastrointestinal side effects of GLP-1 receptor agonists in obesity: recommendations for clinical practice. Oral semaglutide: Frontiers in Endocrinology (2021)
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These drugs were approved by the U.S