In osteoarthritis conditions, preclinical models highlight direct anti-catabolic and immunomodulatory actions (e.g., liraglutide reduces IL-6, MMP-3) [45]
Los medicamentos GLP-1 que se utilizan para tratar la obesidad estn actualmente aprobados para la prdida de peso en adultos con un IMC de 30 o ms o un IMC de 27 o ms en aquellos que tambin tienen problemas mdicos relacionados con el peso
Thyroid dysfunction, insulin resistance, polycystic ovary syndrome, certain medications (like corticosteroids or some antidepressants), and hormonal imbalances can all impair weight loss response to semaglutide
Nevertheless, because sulfonylureas are generic drugs and very inexpensive, they continue to be used and play a role in the management of patients with T2DM
It's their choice
Should minimal early change be read as treatment failure