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The vasoprotective effects are most evident in models of diabetic retinopathy, where a hallmark of the disease is the breakdown of the BRB and subsequent retinal vascular leakage [61]

Since other medications included in these combinations, like paroxetine or minoxidil, are also prescribed for daily use, tadalafil makes the most sense as an adjunct ED medication alongside them

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This brings up a potential drawback to the use of GLP-1 analogs in IBD, since patients may already be experiencing diarrhea or other symptoms in their digestive tract due to their disease

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