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Its worth noting that AOD-9604 was very well tolerated in trials, with no major safety issues reported

As our results showed, there is no difference between them in terms of efficacy, but in terms of patients tolerance, advantages, and disadvantages of each route, the sublingual route is preferred over IM and oral routes

[DOI: 10.1371/journal.pmed.1000100] [DOI] [PMC free article] [PubMed] [Google Scholar] Lindenbaum 1994 Lindenbaum J, Rosenberg IH, Wilson PW, Stabler SP, Allen RH

While this efficiency is generally beneficial, in environments of excess caloric intake it may contribute to fat accumulation