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Microdosing GLP-1s for cosmetic weight loss: Patients are asking me about it, TV and online ads are promoting it, friends are speculating about whos doing it

Neuropharmacology 229 , 109477 (2023)

The proposed effects of sermorelin (increased lean muscle mass, improved sleep quality, enhanced recovery, and metabolic benefits) remain largely theoretical or anecdotal in adults without documented growth hormone deficiency

In animal models of HF, GLP-1R agonists increase myocardial glucose uptake [62], stroke volume and LVEF, accompanied by decreasing LVEDP and systemic vascular resistance [63]

Standard dosing ranges Typical daily doses: Beginner: 100-200 mcg per day Standard: 200-300 mcg per day Advanced: 300-500 mcg per day (usually split) Key principle: Ipamorelin follows a bell-shaped dose-response curve

Post-procedure recovery