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RSL3 is a chloroacetamide-containing covalent ligand with two stereocenters, with only one of four stereoisomers displaying highly potent GPX4 inhibition 39

Cycle Length Typically 4-12 weeks depending on injury severity and treatment goals

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Klotho The antiaging protein -Klotho is a 130 kDa membrane-bound protein mainly synthesized in the kidneys and acting as a coreceptor for FGF23, thereby mediating its renal effects with respect to phosphate handling and calcitriol synthesis [80]

PMID: 21795440