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Hence intracellular proteins usually do not contain disulfides, which are abundant in extracellular proteins (such as those found in blood) or in certain organelles such as the endoplasmic reticulum and mitochondrial intermembrane space where disulfidesc can be introduced

However, peptides have intrinsic weak points, and they did not provide encouraging results in vivo , likely due to their physical, chemical and structural instability and low membrane permeability (112, 119, 121)

Chemical agents targeting GLSs have been studied, and CB-839, 968, and BPTES have been found to exhibit tumor-specific antiproliferative effects 199

J Chem Technol Biotech

One way to treat this condition is via blood transfusion

This is why consistent use matters