Montuori et al
When you take a lifelong medication, you should also be closely monitored by a doctor who understands your health journey
JAMA 325(14):14031413
About 80% of the patients were taking it for diabetes reasons, and among the total cohort, that average weight loss at 1 year was 5%
On the other hand, methimazole should be administered cautiously in older persons with an appropriate dose, not only because of the concern for higher rate of agranulocytosis,87 but also probably because of more susceptibility of these patients to the hepatic injury induced by this drug.88 In conclusion, no clear and direct relationship between patients' age and antithyroid agents-induced hepatotoxicity has been founded yet, except for a higher rate of PTU-induced liver damage in pediatrics by an unknown mechanism(s)
Oxidative stress, which results from the overproduction of reactive oxygen species (ROS), causes cellular oxidative injury such as lipid peroxidation, protein oxidation, and DNA damage (Ishihara et al., 2012)
