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doi: 10.1016/j.phrs.2025.107643 56 CaiYDongZWangJ

SURMOUNT-1, published in the New England Journal of Medicine, reported mean weight reductions of up to approximately 22.5% at the highest dose over 72 weeks results that set a new benchmark for pharmacological weight reduction in clinical research

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By delaying gastric emptying and slowing intestinal transit time, the medication can disrupt this process, leading to inconsistent bowel movements

Retatrutide is a synthetic triple receptor agonist activating GLP-1, GIP, and glucagon receptors simultaneously, studied as a next-generation metabolic research compound