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Key findings (Vafaei et al., 2025): 30-50 mg/kg mirtazapine: dose-dependent seizure suppression Mediated by CB1/CB2 activation (proven by antagonist blockade) GABA-independent mechanism (distinct from benzodiazepines) Appetite/weight gain provides in-vivo functional validation of CB1 engagement The broader implication: Clinicians and researchers have been using ECS pharmacologyunknowinglyfor decades

Relevant examples (not exhaustive): (7) Absorption: Penicillin should be taken on an empty stomach but amoxicillin and co-amoxiclav can be taken with or without food

doi: 10.1038/s41598-021-00070-7 10 CaniP

Because they slow digestion and suppress appetite, your body can become: Dehydrated or constipated due to sluggish digestion Undernourished from eating less food (and fewer nutrients) Fatigued from protein or calorie deficits Losing lean muscle instead of just fat Experiencing gut microbiome disruption Craving sugar or carbs due to blood sugar dips Meet your new GLP-1 sidekicks: our GLP-1 Support Supplements

By adding the peptide-induced pulse on top of this, you can achieve a profound synergistic effect