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TRIUMPH-4 (December 2025): Topline results from the Phase 3 TRIUMPH-4 investigational trial evaluating the triple hormone receptor agonist in adults with obesity or overweight and knee osteoarthritis, without diabetes, met all primary and key secondary endpoints, with substantial reductions in body weight and improvements in knee pain and physical function also observed

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The study also revealed the mechanism by which 2-AR participates in liver regeneration, 2-AR recruits G-protein-coupled receptor kinase 2 to the cell membrane, where it forms a complex with the c-met receptor, activating the downstream ERK signaling pathway and thereby promoting hepatocyte proliferation

A double-blind, placebo-controlled parallel trial of vitamin C treatment in elderly patients with hypertension