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Regulating the gut microbiota can alter their ability to produce TMA, which may be a reasonable intervention strategy for the prevention or treatment of TMAO-induced metabolic diseases ( Lactobacillus Plantarum ZDY04 can significantly reduce the content of TMAO in serum and TMA in the cecum by regulating the structure of gut microbiota community, and effectively inhibit the development of atherosclerosis in mice ( Lactobacillus paracsei , the production of TMA was reduced, but TMAO level remained unchanged

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