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doi: 10.1002/14651858.CD008870.pub2 5 CaiZWangSLiJ

In Phase 1, generally, small numbers of healthy volunteers are initially exposed to single escalating doses and then multiple escalating doses of the product candidate

Quantitative real-time PCR Cytosolic mtDNA determination: Mitochondrial isolation was conducted following the manufacturers protocol for the Mitochondrial Isolation Kit (Beyotime, C3606), freshly dissected hippocampal tissue from mice were weighed and cut into small pieces

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The amount of estradiol produced during the menstrual cycle varies a lot in different women (see Panel A of Figure 3)