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However, contrasting data from other studies showed that the addition of PDE4i rolipram to standard TB treatment accelerated mortality, increased the bacterial burden, and did not reduce the time to bacterial clearance in the lungs of a mouse model of TB [34], raising concerns about the general applicability of PDE-Is

Diabetes Obes Metab 23:20582066 Mosenzon O, Capehorn MS, De Remigis A, Rasmussen S, Weimers P, Rosenstock J (2022) Impact of semaglutide on high-sensitivity C-reactive protein: exploratory patient-level analyses of SUSTAIN and PIONEER randomized clinical trials

Gastroenterology 143:913916

Hoog MM, Kan H, Deger KA, et al

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It is not scheduled under the Controlled Substances Act