Research continues to explore the broader therapeutic potential of GLP-1, including its effects on the cardiovascular system, brain function, and its potential role in the treatment of conditions beyond type 2 diabetes, such as Parkinson's disease and Alzheimer's disease
Methods We analyzed de-identified electronic health records of 7856 subjects with T2D treated with GLP-1 M drugs at Vanderbilt University Medical Center from 20032019
+The effect of GLP-1R agonists on brain mechanism is less than 50% (relative to the control group and the AD group without GLP-1R agonists)
A double stainless steel guide cannula (26 gauge in diameter, Phymep, France) was implanted into the OB through stereotactic procedures (A/P: +4.8 mm from bregma, M/L: 1 mm and D/V: 1.7 mm from brain surface) after exposing and properly scrubbing the skull of the animal
That may sound simple, but it's a major mindset shift
GLP-1 is notably produced by hindbrain PPG neurons, mainly in the nucleus tractus solitarius (NTS) and the medullary intermediate reticular nucleus (IRT) 4