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This overactivity in GBC cells is hereby inhibited, which leads to reduced invasiveness and EMT, which is important for metastasis in cancer cells
Due to the increased release of PAI-1 and the thrombin activatable fibrinolysis inhibitor from liver and dysfunctional VAT, high-fat diet and obesity inhibit plasminogen activators (PAs) (e.g., t-PA and urokinase-type plasminogen activator) thus preventing clot dissolution [48, 49]
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Zinman B, Aroda VR, Buse JB et al (2019) Efficacy, safety, and tolerability of oral semaglutide versus placebo added to insulin with or without metformin in patients with type 2 diabetes: the PIONEER 8 trial
10.1016/j.neuint.2007.03.012 136
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