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J Cell Mol Med (2009) 13:422938.10.1111/j.1582-4934.2008.00463.x 81 LiuXSolehdinFCohenILGonzalezMGJenkinsECLewisMEet alPopulation- and family-based studies associate the MTHFR gene with idiopathic autism in simplex families

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In PTSD mice models, trauma exposure increased tyrosine hydroxylase expression (the rate-limiting enzyme in catecholamine biosynthesis), elevating stress hormones epinephrine and norepinephrine in serum and colon, which upregulated claudin-2 expression, confirming gut barrier dysfunction (Yadav et al., 2023)