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5.2 Acute Pancreatitis Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists, including WEGOVY [see Adverse Reactions (6)]

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Mechanism mapping (Nature Communications, 2025) Identified the disordered p53 transactivation domain as the binding target, adding structural detail to the mechanism