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This is because all retinoids have to be converted to Tretinoin, AKA Retinoic Acid

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EAU guidelines have recommended a series of evaluation as a routine part of the initial assessment of men with LUTS, that includes clinical history, a validated questionnaire to assess symptoms, physical examination, creatinine measurement, urinalysis, flow rates, postvoid residual (PVR) volume and serum prostate-specific antigen (PSA) measurement especially when a diagnosis of prostatic carcinoma is required [9]

That gap matters when designing dosing schedules

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