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Therefore, there is still the need for the discovery and/or development of a drug candidate characterized by at least a comparable pain-relieving effect to opioids but with a much better safety profile in terms of expected adverse reactions

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That is $240 wasted per month on a protocol that could have worked by simply shifting injection time to bedtime (Nass et al., J Clin Endocrinol Metab, 2008)

In this study, we used hippocampal cultures, electrophysiology, live imaging, immunofluorescence and genetic transfections to fill the existing gap of information on long-term actions of BDNF on synaptic dynamics

Liu et al., 2022)