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GLP-1 has been shown to act through PKA and EPAC (cAMP dependent mechanisms) to inhibit ATP-regulated potassium channels (Kang et al., 2006

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"None of them have gone through what would be considered adequate clinical trials, but nonetheless many people are taking these

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Its a paradox that speaks to how treatments like semaglutide (Wegovy) and tirzepatide (Mounjaro) affect more than just appetite