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According to the working model, these cysteine residues may undergo chemical modification/remodeling including trisulfide bond formation and/or related reactions, resulting in a regional (minor, but effective) structural alteration that enhances c-met binding and the nitration resistance of Y198-HGF
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As TB-500 appears to be well-tolerated by test subjects while offering a range of potentially beneficial biological effects, researchers interested in conducting long-term research have multiple avenues that they may wish to explore
Similar to oridonin, none of the other five compounds tested generated multiple eryptosis phenotypic hallmarks on either nave or infected erythrocytes
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