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Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G(s) proteins

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List of GLP-1 agonists GLP-1 agonist medications currently available in South Africa include: Dulaglutide (Trulicity) Exenatide (Byetta) Liraglutide ( Giliptra, Victoza, Saxenda) Semaglutide (Ozempic) Lixisenatide: Brand name Soliqua

Tirzepatide activates both GLP-1 and GIP receptors simultaneously, creating a dual-hormone effect that targets appetite centers and blood sugar regulation through two independent pathways

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