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United States Pharmacopeia (USP)

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The active component, icariin, acts as a PDE5 inhibitor, similar to Viagra, though it is considerably less potent

PE-22-28 also activates serotonergic neurons in the dorsal raphe nucleus, the brain region that serves as the primary source of serotonin projections throughout the central nervous system

A 2019 randomized controlled trial of lipotropic injections (methionine, inositol, choline, B12) versus saline placebo in 120 participants on ad libitum diets found 0.8 kg (1.76 pounds) difference at 12 weeks, not statistically significant (p=0.18) (Karbalay-Doust et al., Journal of Research in Medical Sciences , 2019)

An intravenous (IV) treatment called the "hangover drip" is intended to relieve hangover symptoms quickly