It targets melanin synthesis without significantly affecting melanocyte cells themselves meaning it's working on the pigment-production pathway, not causing cell damage
However, some people experience nausea or gastrointestinal discomfort with semaglutide, and certain dairy products could exacerbate these symptoms for sensitive individuals
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Those with severe hepatic impairment should avoid this medication due to insufficient safety data
In 2026, retatrutide still does not have a standard U.S