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By potentially downregulating TGF-1, AHK-Cu may alter these cellular processes, possibly affecting cell growth and the immune response at a cellular level

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30,31 In addition, mitochondrial oxidative stress may also trigger the phosphorylation of glycogen synthase kinase-3 (GSK-3), which activates the mixed lineage kinase 3 (MLK3) protein

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J Clin Periodontol 2009