Biological and biophysics aspects of metformin-induced effects: cortex mitochondrial dysfunction and promotion of toxic amyloid pre-fibrillar aggregates
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Inclusion criteria: Children suffering from chronic viral hepatitis or hepatitis of unknown etiology
Symptoms include trembling, sweating, confusion, palpitations, hunger, and irritability
Consistent with human observations, H2O2 also promoted FOXO4 nuclear translocation in TM3 cells, along with an increase in senescence markers p53, phospho-p53, and p21, while reducing testosterone synthesis-related enzymes like CYP11A1 and CYP17A1