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An exploratory analysis of SURPASS-4, demonstrated that tirzepatide may have renoprotective actions compared to insulin glargine and these benefits were more pronounced in people with impaired kidney function, supporting the design of future clinical trials with tirzepatide in people with pre-existing kidney disease

Heer CD, Sanderson DJ, Voth LS, Alhammad YMO, Schmidt MS, Trammell SAJ, et al

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The liposomal delivery system encapsulates active peptides within phospholipid spheres, helping protect them through the digestive process and promoting enhanced uptake