Under normal conditions, NAPQI is detoxified by conjugation with GSH
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Activity regulated by mechanical stress, hormones (GH, IGF-1, PTH), local growth factors (BMPs, TGF-), and inflammatory signals
doi:10.21037/tau-20-685
Glutamate, at the interface between amino acid and carbohydrate metabolism
However, in some special circumstances or at special time points, treatment with GH may also increase DNA damage or decrease DNA damage repair, such as exposing GH to the GHD Lewis dwarf rats and Snell dwarf mice in prepubertal results in decreased DNA repair by leading to dysregulation of DNA damage proteins (Podlutsky et al., 2017)
