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In large randomized controlled trials, patients receiving semaglutide 2.4 mg lost a mean of 6% of their weight by week 12 and 12% of their weight by week 28, Wissam Ghusn, MD, postdoctoral research fellow from the division of gastroenterology and hepatology of the Precision Medicine for Obesity Laboratory at Mayo Clinic in Rochester, Minnesota, and colleagues wrote

The brain is protected by the blood-brain barrier (BBB)a dense layer of endothelial cells joined by tight junctions that prevents most circulating molecules from entering neural tissue

High-Protein Diets and Amino Acid Breakdown 7