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Backbone plasmids and target DNA fragments were digested with restriction enzymes (New England BioLabs), followed by ligation using T4 DNA ligase (EL0011, Thermo Fisher Scientific)

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Funding This study was financed in part by the Coordination of Improvement of Higher Education Personnel (CAPES) BrazilFinance Code 001

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Ohkubo 1994)

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doi: 10.1038/s41467-023-40923-5

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