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Uric acid may be protective against cognitive impairment in older adults, but only in those without cardiovascular risk factors

however, this is constrained by ethical and economic reasons

Univariate ANOVA (significant threshold p 90% loss of kidney function as judged by measured GFR 34

For genotypes that were not well-represented, the subtypes were all represented under the genotype

Lab testing is not always required but is often recommended to establish baseline hormone, metabolic, and inflammatory markers

To account for the potential impact of IBT on the outcomes of the NMA, these five trials were excluded from the networks (although it is noted that participants in the remaining studies in the network may also have received dietary and exercise advice)