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Preclinical data further indicate that liraglutide activates the SIRT1 signaling cascade, suppresses atrophy-related genes, and upregulates myogenic differentiation factors, thereby protecting against obesity-induced muscle atrophy and contributing to structural muscle integrity [14, 16]
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Insulin resistance, in turn, may affect fatigue, cardiovascular risk, and general health in people already managing a chronic neurologic disease
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