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Although preclinical data generally suggest a positive impact of adiponectin on bone homeostasis through the reduction in osteoclast activity and the increase in osteoblastic differentiation, clinical studies present conflicting results

Particularly, Semaglutide induced central c-Fos activation in 10 brain areas, including hindbrain areas that it directly targets, as well as secondary regions without direct GLP-1R interaction, such as the lateral parabrachial nucleus (LPB)

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