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One of the main pathways researchers talk about is AMPK, which is sometimes described as a cellular energy sensor. When AMPK is activated, the body may improve glucose uptake, reduce glucose production in the liver, and support fatty acid use, which is why berberine has been studied for blood sugar, insulin resistance, cholesterol, triglycerides, and fatty liver-related conditions. She continues, This is why berberine is sometimes compared to Metformin, because Metformin also affects metabolic pathways

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