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However, CBD significantly decreased the expression of pro-apoptotic Bax and Casp3 genes in the cells and overexpressed the expression of anti-apoptotic Bcl-2 gene, indicating that the neuroprotective impacts of CBD are through the reduction of the apoptosis signaling pathway

Structure Therapeutics' aleniglipron, an oral small-molecule GLP-1 agonist, posted the highest efficacy among oral candidates: 16.3% weight loss at 44 weeks in Phase 2 with only 2% discontinuation due to side effects

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[DOI] [PubMed] [Google Scholar] Noe F

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