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WenzelPSchuhmacherSKienhferJMllerJHortmannMOelzeMet alManganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction
11/420,168 pursuant to a Request for Continued Examination of application Ser
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Mechanistic studies have revealed that the application of Gln metabolic inhibitors or the knockdown of the transmembrane protein SLC1A5 can inhibit the YAP1/TEAD signaling cascade, which is known to promote mesothelioma invasion and metastasis ( 2.1.2 Promoting drug resistance in tumor cells The dysregulation of Gln metabolism is closely associated with the development of tumor resistance ( In ovarian cancer, the levels of Gln, glutamate, and GSH in the cisplatin-resistant cell line A2780cis were significantly higher than those in the A2780 cells, while the expression of GS decreased
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