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While BSO exhibits some anti-tumor activity, its clinical investigation is still very limited, necessitating additional research to determine its safety and efficacy in cancer therapy

These include a history of infection, the use of certain drugs, especially TNF- inhibitors, smoking, alcohol, and stress (195, 199)

Reduced symptoms of post-traumatic stress disorder (PTSD): NAD+ therapy has shown promise in reducing symptoms of PTSD

Subsequently, IGF-I heterozygous mice on CD-1 background were analyzed and demonstrated a reduction in cortical bone mineral density associated with decreased serum IGF-I levels, suggesting that IGF-I is a determinant of bone mass in postnatal life

Endocrinology 155 8997 10.1210/en.2013-1556 [DOI] [PMC free article] [PubMed] [Google Scholar] Muller F