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Astrocytes can at least temporarily switch to the glycolytic pathway to support their own energetics, and can use their glycogen pool (of which they are the sole possessors in the CNS 205,206 ) to produce lactate and support energy substrate-deprived neurones

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69 Importantly, toxicology studies in animals have been done as well

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The head of SR146131 overlies the pocket formed by TM6ECL3TM7, and foot A (phenyl ring) stands on TM3TM6, whereas foot B (cyclohexane ring) stands on TM2 and TM7 (Fig