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The article lists personal history of medullary thyroid carcinoma, MEN2 syndrome, severe renal impairment, and active diabetic retinopathy complications

In trials, overall GI events rose with higher doses and faster escalations

Previous physiological studies have shown that both GIP (113116) and GLP-1 (117) act in concert with glucose to enhance insulin gene transcription, mRNA stability, insulin biosynthesis, and insulin secretion

Faurschou A, Gyldenlve M, Rohde U, et al

Given that this condition predominantly affects children, dedicated pediatric registries and long-term studies are essential to address the paucity of data on developmental safety, effects on linear growth and pubertal progression, and long-term cardiometabolic outcomes

GPCR heteromers: An overview of their classification, function and physiological relevance