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Mounjaro has to be titrated when it is started, meaning a gradual dose increase happens over many months, to allow the body to adjust to the medication and lower the risk of side effects, says Florencia Halperin, MD, a Boston-based endocrinologist who is the chief medical officer of the weight loss clinic Form Health

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So it was very important for our chain of thought and decision early on that we actually knew that GLP-1 had these separate effects and that they could work in the brain and have a separate effect on well-known pathways in the brain

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The GLP1R rs6923761 variant correlates with variable GLP-1 efficacy

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