Importantly, their influence extends to skeletal muscle, where GLP-1 RAs promote glucose uptake via the AMP-activated protein kinase pathway, increase vascular blood flow, and mitigate glucotoxicity, thereby supporting muscle protein synthesis and inhibiting catabolic pathways [14, 15]
65 Some studies suggest benefits start even above 1.0 g/kg/day compared to lower intakes
These two measures have been shown to help preserve muscle mass and strength in people with obesity during weight loss, per research in Nutrients
10.1007/s13311-019-00805-5 57 ScrocchiL
While PYY and GLP-1 both decrease appetite, increase satiety, and slow gut motility, PYY also improves insulin sensitivity, while GLP-1 functions as an incretin to potentiate glucose-stimulated insulin release, in addition to having an antiapoptotic effect on B cells, which results in increased B cell mass
"Supplements can't replace the medication" doesn't mean "supplements do nothing." Your body does produce its own GLP-1 in response to food, and certain dietary choices and ingredients can support healthy blood sugar, digestion, and satiety
