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From its initial use in the treatment of type 2 diabetes to its expansion to 12 indications such as obesity, cardiovascular disease, chronic kidney disease, and metabolic dysfunction related fatty liver disease (MASLD), the annual sales of GLP-1 drugs exceeded 100 billion dollars, and its research and development funding reached a historical peak of 21.72 million dollars in 2025

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Recent studies employing various robust designs such as randomized, prospective, double-blind, placebo-controlled, crossover, comparative, non-randomized, contralateral, interventional, randomized parallel, longitudinal, and investigator-masked approacheshave highlighted the effectiveness of castor oil, derived from Ricinus communis , as a promising therapeutic option for managing a range of ocular surface diseases [328]

And while short-term pain may be frustrating, the long-term benefits of PRPimproved pain, reduced inflammation, increased mobility, and lasting pain reliefare well worth the temporary discomfort

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