2022;8(13) doi: 10.1126/sciadv.abi8807
As for Polyphenol Booster, it contains: Pomegranate extract (375mg) , shown in a 2022 study to increase short-chain fatty acids and regulate GLP-1 secretion at 375mg doses,32 while a 2025 study found that pomegranate in general can help proliferate beneficial bacteria, including Akkermansia 33 Grape seed extract (275mg) , which produces a significant prebiotic effect on Akkermansia , as in a 2021 study that used 200mg doses34 Green tea extract (225mg) , which also favors Akkermansia proliferation,35 potentially at doses as low as around 50mg in a 150lb human (as suggested by mouse studies)36 All very well-dosed to support Pendulums probiotic supplements
Most trials showing benefit used multi-strain formulations alongside caloric restriction, making it difficult to isolate probiotic effects
(Quality-of-life measures generally improve as obesity and its symptoms remit, although formal QoL endpoints have been reported only in a limited fashion)
GLP-1 receptor agonists mimic the incretin hormone GLP-1, which stimulates insulin secretion, suppresses glucagon, slows gastric emptying, and promotes satiety
This keeps tissue hydrated and comfortable, removing one barrier to desire
