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Mature islet cells lack the expression of YAP, while overexpression of YAP in islets is associated with proliferative and antiapoptotic effects

mTOR is induced by Flt3 ligand (Flt3L) and is necessary for the Flt3L-driven development of DCs [100], and mTOR inhibits IL-1 production to impede DC maturation and the ability to stimulate effector T cell responses

Companion diagnostics may play a larger role in peptide therapeutics, particularly for targeted therapies in oncology and other conditions where biomarker-driven treatment selection improves outcomes

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