glp 1 analogues side effects GLP-1 Analogue Clinical Recommendations to Manage Gastrointestinal

Compared with GLP-1, dual agonists can avoid the degradation of dipeptidyl peptidase-4, thereby prolongating drug administration

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Suppresses Glucagon Secretion: It also acts on the alpha cells of the pancreas to reduce the secretion of glucagon, a hormone that tells the liver to release stored glucose

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Patients may need a more careful discussion if they have a history of: Previous NAION in one eye Significant optic nerve crowding Diabetes with vascular complications Sleep apnea, especially untreated sleep apnea High blood pressure or low nighttime blood pressure Cardiovascular disease Sudden unexplained vision loss in the past This does not automatically mean a GLP-1 medication is unsafe, but it does mean the patient should have a personalized risk-benefit discussion with their medical provider