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Melatonin promotes uterine and placental health: potential molecular mechanisms

45.3% of participants on the highest dose lost 30% or more of their body weight TRIUMPH-4 knee osteoarthritis + obesity (Dec 2025) 28.7% weight loss at 68 weeks TRANSCEND-T2D-1 type 2 diabetes (Mar 19, 2026) A1C -2.0%, 16.8% weight loss at 40 weeks TRIUMPH-2 obesity with type 2 diabetes, nested OSA protocol (July 23, 2026) 20.8% weight loss at 12 mg over 80 weeks

Nature Biotechnology, 39, 28-29

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24 The main reason to diagnose and treat these slower-growing, less invasive tumours is to avoid ulceration and disfigurement, as a large BCC can require significant reconstruction after removal