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Longevity signals (preclinical): Some long-term rodent studies describe lifespan-related effects framed as hypotheses, not proven benefits

T-cell receptor V gene use in autoimmune thyroid disease: direct assessment by thyroid aspiration

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Consequently, misfolded and polyubiquitinated proteins accumulate in the ER, triggering the unfolded protein response (UPR) and, ultimately, neuronal death